منابع مشابه
SIRT2 Regulates LPS-Induced Renal Tubular CXCL2 and CCL2 Expression.
Sirtuin 2 (SIRT2), a NAD(+)-dependent histone deacetylase, is involved in carcinogenesis and genomic instability and modulates proinflammatory immune responses. However, its role in renal inflammatory injury has not been demonstrated. In this study, we explored the expression patterns of CXCL2 and CCL2 in kidney tissue from Sirt2(-/-) and Sirt2(+/+) mice and in mouse proximal tubular epithelial...
متن کاملRadiation-induced kidney injury
*Corresponding author: Milad Baradaran-Ghahfarokhi, Medical Physics and Medical Engineering Department Isfahan University of Medical Sciences, Isfahan, Iran. E-mail: [email protected] The kidneys are vitally important, responsible for producing erythropoietin to stimulate red blood cell production, filtering waste metabolites and electrolytes from the blood, and modulating blood pressure...
متن کاملRadiation-induced Lung Injury
membrane, and are just wide enough to allow the passage of red blood cells, one cell at a time. The alveoli are lined with specialized epithelial cells termed Type I pneumocytes. Interspersed among these cells are surfactant-producing Type II pneumocytes. Within the alveolar wall, pneumocytes are separated from endothelial cells by their associated basement membranes and a potential stromal spa...
متن کاملEstablishment of a rat model of radiation-induced lung injury
Background: Radiation-induced lung injury is a refractory side effect in lung cancer radiotherapy, the mechanism still remains unclear, hence an appropriate animal mode may become useful to investigate it. Materials and Methods: 50 female Wistar rats were randomly divided into 5 groups, average 10 rats/cage: A. control group B. 3Gy×10f C. 6Gy×5f D. 12.5Gy×1f E.15.3Gy×1f....
متن کاملTranscriptional corepressor MTG16 regulates small intestinal crypt proliferation and crypt regeneration after radiation-induced injury.
Myeloid translocation genes (MTGs) are transcriptional corepressors implicated in development, malignancy, differentiation, and stem cell function. While MTG16 loss renders mice sensitive to chemical colitis, the role of MTG16 in the small intestine is unknown. Histological examination revealed that Mtg16(-/-) mice have increased enterocyte proliferation and goblet cell deficiency. After exposu...
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ژورنال
عنوان ژورنال: Radiation Research
سال: 2019
ISSN: 0033-7587
DOI: 10.1667/rr15282.1